Tumor Lipids

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Tumor Lipids

Labeled long chain acyl-CoA, aldehyde, and alcohol (16:0) were incubated in the peritoneal cavity of mice bearing Ehrlich ascites cells and the distribution of radioactivity in the acyl, alkyl, and alk-1-enyl moieties of various neutral lipid and phospholipid classes was compared. The results suggested the following metabolic relations. 1. Alkyl glyceryl ethers are precursors of alk-l-enyl glyc...

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Tumor Lipids BIOSYNTHESIS

Labeled long chain acyl-CoA, aldehyde, and alcohol (16:0) were incubated in the peritoneal cavity of mice bearing Ehrlich ascites cells and the distribution of radioactivity in the acyl, alkyl, and alk-1-enyl moieties of various neutral lipid and phospholipid classes was compared. The results suggested the following metabolic relations. 1. Alkyl glyceryl ethers are precursors of alk-l-enyl glyc...

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Tumor lipids: characterization of the lipids isolated from membranous material.

Membranous material was prepared from Ehrlich ascites carcinoma cells by tonal centrifugation. The distribution of fatty acids among the individual neutral lipid and phospholipid classes isolated from the membrane preparation was determined. Survey electron microscopy indicated that the preparations consisted of vesicles of rough surfaced endoplasmic reticulum, lysosomal-like structures, virus-...

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Immunochemical studies of organ and tumor lipids . XIX . Cytolytic

Rabbit antisera to rat lymphosarcoma contain antibodies that are cytolytic for rat erythrocytes in the presence of complement. The reaction can be inhibited completely by pure cytolipin R showing that (u) immune hemolysis can be mediated through lipid determinants in the membrane, and ( b ) that cytolipin R determinants are present in the intact erythrocyte membrane and exposed on the surface. ...

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Hydrolysis of tumor cell lipids after CTL-mediated death.

Contributions of lipases to CTL function have been debated, including if T cell lipases damage target cells. Expression of the lipase pancreatic lipase-related protein 2 (PLRP2) was previously found in IL-4 cultured lymphocyte cell lines but absent from IL-2 cultured lymphocytes. Here, we evaluated IL-2 and IL-4 induced CTLs for hydrolysis of target cell lipids and killing. Using anti-CD3 redir...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 1970

ISSN: 0021-9258

DOI: 10.1016/s0021-9258(18)63118-7